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In mice subjected to transverse aortic constriction (TAC), a model of pressure overload-induced heart failure, cardiomyocytes exhibit severe hypertrophy and mitophagy activation

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More specifically, the researchers shared that " Experiments utilizing an ESR spin-trapping technique revealed that, among hydroxyl (OH), superoxide (O2-), and peroxyl (ROO) radicals generated by respective chemical reaction systems, GHK diminished signals of both OH and ROO

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