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86 ZhangJ.XuY.CaoT.ChenJ.RosenB
180,181,183 GLP-1 also activates the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, which is crucial for maintaining the survival and function of pancreatic -cells
Emerging evidence suggests that ALC levels are reduced in individuals with MDD, and this deficiency may contribute to depressive symptoms through disruptions in mitochondrial fatty acid transport, neuroplasticity, and neurotransmission
Unlike other weight loss treatments, such as Semaglutide, which only acts on one receptor, Tirzepatides dual approach provides enhanced weight loss results
Additionally, it is believed that the PPG neurons are not the only source of GLP-1 in the brain, as gut-derived GLP-1 has been implicated in satiety studies to exert its effects on the brain as well [52]
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