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(PubMed) Kupka R, Mugusi F, Aboud S, et al

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The two protein molecules are not the right shape to bond to each other, and so a 'linker molecule' is required that joins the two together

Preclinical research in animals using GLP-1-estrogen conjugate molecules found that the combination decreased fasting blood glucose and improved insulin sensitivity to a greater extent than GLP-1 alone [4]

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The reduction in appetite typically begins within the first few weeks of treatment