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In microglia, several key inflammatory regulators near the APOE locus 57 showed opposing regulation by LPS and semaglutide, including Clptm1 , Relb , and Bcl3 (Supplementary Fig
A separate regulatory status This is the major asymmetry between the two
Smaller divided doses may reduce these fluctuations
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Think of the three receptor arms as brake, buffer, and burner
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