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Connelly et al

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[73] [74] Endocrine actions [edit] Valproic acid has been found to be an antagonist of the androgen and progesterone receptors, and hence as a nonsteroidal antiandrogen and antiprogestogen, at concentrations much lower than therapeutic serum levels

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This contrasts with recombinant GH supplementation, where no such feedback operates and supraphysiological IGF-1 can be sustained indefinitely

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