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Dihexa and its analogs bind with high affinity to HGF, induce c-Met phosphorylation in the presence of subthreshold levels of HGF, stimulate hippocampal spinogenesis and synaptogenesis equivalent with HGF [81], and promote neurogenesis and cerebro protection (data in preparation for publication)
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The protection against overdose death was unforeseen but clearly of enormous potential clinical benefit. The study was published this week online ahead of print in the journal ACS Chemical Biology
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