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However, whilst intravenous infusion of GLP-1 was effective (16), the insulinotropic effect of a single subcutaneous injection was surprisingly short-lived, with insulin levels peaking at 30 min before returning toward baseline within 90 min, even though glucose levels were still well within the hyperglyacemic range and circulating immunoreactive GLP-1 levels were significantly elevated for several hours (17)

Khorram O, Laughlin GA, Yen SS

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