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The standard hangover remedies, hydration, electrolytes, rest, bland food, apply but may be less effective than pre-tirzepatide
These are not signs that something is wrong
CrossRef Circulating GDF15 levels reflect metabolic and inflammatory burden in early dysglycemia: findings from the ADIOS cohort Ji Yoon Kim, Ah Hyeon Lee, Jiyoon Lee, Hye-Min Jang, Sin Gon Kim, Dong-Hoon Kim, Nam Hoon Kim Diabetes Research and Clinical Practice.2026
Below a graph showing mean BMI change over time by baseline BMI category in SURMOUNT-1 through SURMOUNT-4 is positioned along a well-known graph from the SURMOUNT-4 study showing weigh regain in placebo arm after open-label lead-in period, and not less known graph from STEP-1 study with weight regain dynamic in off-treatment extension period
Clinical observations from practitioners are positive