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Too much NNMT can lower NAD+ levels (low NAD+ levels may make it harder to burn fat efficiently or maintain metabolic health as you age)
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Unlike full-length growth hormone, AOD-9604 does not stimulate IGF-1 production or interact with traditional growth hormone receptors, indicating an independent mechanism of action that has been the subject of ongoing investigation
Later work examined NNMT inhibition combined with dietary changes in obese mice, reporting reductions in body weight, fat mass, and hepatic fat, alongside shifts in gut bacterial populations
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