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Collectively, these data confirm the functional absence of MZB in Gclc fl/fl Mb1-Cre + mice and demonstrate that Gclc is critical for FoB-mediated GC reactions and antibody-mediated immunity to infections

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Given potential sex differences, we also conducted sex-specific analysis using individual data from the UK Biobank

Risk of bias was assessed for these trials using the Cochrane Risk of Bias 2 tool, and domains such as randomization, blinding, and incomplete outcome data were considered when interpreting the pooled estimates