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In accordance, geniposide increased -cell proliferation in diabetic mice and triggered small islet-like cell cluster formation as a result of -cell neogenesis from ductal epithelium, which was well correlated with an increase in TCF7L2 expression (88)
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Sample size calculation assumed a difference of at least 12% in mean per cent weight reduction from randomization to week 72 for tirzepatide MTD as compared with placebo, a common s.d
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Subsequent haemodynamic assessments did not show any adverse effects of any of the treatments on heart rate or arterial blood pressure in lean mice receiving treatment for 14 days (Extended Data Fig
The study included 155 controls (55 girls) and 15 patients each with episodic migraines (9 girls) and chronic migraines (10 girls)
