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But yes, a needle is involved

long-term safety and efficacy in humans have not been established

If the deficiency is detected, metformin can be continued while the deficiency is corrected with B 12 supplements

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High-dose oral therapy (10002000 micrograms daily) can be effective even in pernicious anaemia, as approximately 1% of B12 is absorbed through passive diffusion independent of intrinsic factor

they might slow down future injections or ensure you havent taken other vasodilators (like hot drinks or exercise immediately prior) that could amplify that effect