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Therefore, TGR5-selective agonists, such as INT-777, RDX8940, show promising effects in improving energy metabolism, reducing inflammation and stimulating energy expenditure (Pellicciari et al., 2009

Pancreatic -cells: glucose-dependent insulin secretion enhancement (insulin release only when blood glucose is elevated, limiting hypoglycemia risk) and -cell proliferation, with simultaneous -cell glucagon suppression reducing hepatic glucose output

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Copper balance becomes critical when supplementing zinc long-term