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A 2022 study published in the Journal of Endocrinology found that skeletal muscle insulin sensitivity peaks in the early morning (cortisol-driven glucose mobilization) and again post-exercise (GLUT4 translocation), creating two distinct windows where IGF-1 LR3 administration produces measurably higher receptor activation compared to random timing

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Most patients can return to their normal routine immediately after the injection, making it a convenient treatment option