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In Boyden chamber assays, TB4 stimulated keratinocyte migration 23-fold over medium alone within 45 hours with as little as 10 pg sufficient to produce a potent stimulatory response
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The UK prescribing information does not list hypothyroidism as a contraindication, though regular thyroid monitoring should continue and levothyroxine doses may need adjustment during weight loss
A follow-up study spanning two years found that while some weight was regained after stopping the medication, testosterone levels remained lower
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