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Oral administration to diet-induced-obese mice for ~10 days reduces fat mass without altering food intake, decreases adipocyte size, restores insulin sensitivity, and increases adipose NAD and SAM levels [2]

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TB-500 (Thymosin Beta-4 Fragment) This peptide is selected in model systems to explore pathways related to actin modulation, tissue biology, and assay readouts for cell motility and matrix interaction

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Well-tolerated in preclinical models at effective dosages