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It has also been shown that the response of GLP-1 to meals is unaffected by small intestinal resections which can interrupt intramural reflux pathways [30]

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The brand cites broader medication-class research in its site footnotes: GLP-1 (semaglutide class): around 0.87% body-weight loss per four weeks in a cited 68-week clinical trial

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Standard GLP-1 contraindications still apply Compounded semaglutide has safety risks and contraindications to consider: Semaglutide is not indicated for patients with a personal or family history of thyroid tumors, particularly medullary thyroid carcinoma (MTC) and neuroendocrine tumors such as MEN 2 (multiple endocrine neoplasia) type 2 syndrome