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Unlike general CKD, where albuminuria is often the predominant driver of progression, the role of collagen IV mutations in AS creates a unique therapeutic target for GLP-1 RAs
Brevetti G, Chiariello M, Policicchio A, and et al
However, the bulk of research is preclinical, with a significant lack of high-quality clinical trials
increase
At the same time, the proposed pathway will require further validation to determine how strongly it operates in human disease, which microbial communities produce the relevant inflammatory signals, and whether interrupting the pathway can preserve dopamine neurons
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