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Neuron-specific overexpression of Mfn2 suppresses LPS-induced IL-1 release in the central nervous system without affecting peripheral inflammation, prevents mitochondrial fragmentation, and attenuates microglial activation through CX3CL1 signaling [105]

Higher doses were associated with increased sensory effects and higher discontinuation rates

Clinical trial results for oral GLP-1 medications have been encouraging

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While both prescription drugs share common side effects, such as gastrointestinal disturbances , Mounjaro may present additional digestive challenges

McBride encourages providers who feel confident managing obesity in primary care to be strategic and proactive in both diagnosing and escalating care