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The corresponding placebo-group changes were small. The pooled Phase 3 analysis included more than 800 participants and confirmed a significant treatment effect on visceral adipose tissue. These results formed the basis of tesamorelins FDA-approved prescription indication

19,65 Although most border-forming reactive astrocytes in narrow zones immediately abutting tissue lesions are newly proliferated, proliferation drops off rapidly with increased distance from lesions, which are surrounded by large areas of intermingled proliferative and non-proliferative reactive astrocytes as well

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Researchers have described this as the compounds key differentiating feature in systematic reviews of the preclinical literature

2006;136(3 Suppl):821S-826S

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