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Description

Introduction Cardiovascular diseases (CVD) are a group of cardiac and vascular disorders including hypertension (HTN), atherosclerosis (AS), myocardial ischemia (MI), heart failure (HF), peripheral artery disease, rheumatic heart disease, and cardiomyopathies (Kolluru et al., 2022)

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In a similar study, ursolic acid demonstrated significant in vitro and in vivo anticancer activity against DU145 and LNCaP prostate adenocarcinoma cells, as well as a mouse model via diminished CXCR4/CXCL-12 signaling axis and reduced activation of NF-B (228)

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McKone EF, Shao J, Frangolias DD, Keener CL, Shephard CA, Farin FM, Tonelli MR, Pare PD, Sandford AJ, Aitken ML, et al: Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease

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