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The remaining phosphate group in 3-phosphoglycerate is an ester phosphate and does not have enough energy to phosphorylate ADP, so a series of isomerization and dehydration reactions is enlisted to convert the ester phosphate into a high-energy enol phosphate
if sustained elevation above 150/95 mmHg occurs, reduce doses by 30-40% on the next administration and extend spacing to 12 hours minimum
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Growth of the segment has been attributed to strong clinical outcomes associated with this class of drugs, including improved glycemic control, reduced appetite, and significant weight reduction
The folate-mediated enzymes TYMS and cSHMT, alongside DHFR, are components within a nuclear multi-enzyme complex located at the replication fork during DNA replication and repair
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