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Additionally, it has been shown to reduce the risk of major cardiovascular events such as heart attack, stroke or death in adults with type 2 diabetes mellitus and established cardiovascular disease
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The LR3 extension does not make it "safer" -- it makes it longer-acting and less regulated by binding proteins, which from a risk standpoint means sustained free IGF-1R activation without the IGFBP buffering system that modulates native IGF-1 activity in healthy physiology
A recent clinical trial has found that in patients with T2DM, tirzepatide performed better than GLP1RAs and dulaglutide monotherapy regarding glycaemic management and body weight reduction
J Biol Chem 259:90829089 Nagy-Szakal D, Barupal DK, Lee B, Che X, Williams BL, Kahn EJR, Ukaigwe JE, Bateman L, Klimas NG, Komaroff AL, Levine S, Montoya JG, Peterson DL, Levin B, Hornig M, Fiehn O, Lipkin WI (2018) Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics
& DAlessio, D
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