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Acknowledgements This work was partly supported by Associazione Italiana Ricerca sul Cancro (AIRC) (IG2014-15197 to L.F.) and by grants from the University of Chieti-Pescara G
Some protocols run to week 16
Thereafter, both branches of the riboflavin biosynthetic pathway merge into one (Figure 1)
Owing to its diverse physiological functions, glutathione has gained interest in the food, cosmetic, and pharmaceutical industries (Al-Temimi et al., 2023)
The rectal route is particularly effective for delivering glutathione as it bypasses the first-pass metabolism in the liver, allowing for higher bioavailability of the medication
That makes it attractive in a market where clear skin and tone care are major consumer goals
