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Tolerability: Where Eloralintide Gets Interesting In the eloralintide Phase 2 study, the most common adverse events were mild-to-moderate gastrointestinal symptoms, and incidence was similar to placebo in the lower dose arms

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Among its three isoforms (endothelial eNOS, neuronal nNOS, and inducible iNOS), nNOS-positive neurons predominantly regulate smooth muscle tone via the NO-cGMP pathway, mediating relaxation of the lower esophageal sphincter, pyloric sphincter, and Oddi sphincter, as well as coordinating gastrointestinal peristaltic rhythms (Idrizaj et al., 2021)

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