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The process of food intake, previously seen as a purely physiologic state of energy homeostasis, is a product of a complex interaction that starts with stomach mechanoreceptors, involving peptide release for stimuli of hunger and satiation (depending on food quantity), peristalsis and gastric accommodation (8387)
While they work in similar ways by mimicking natural gut hormones, their molecular structure is different, which gives them distinct half-lives
Excess weight that has persisted for years or decades involves complex biological adaptations that do not simply reset once the scale shows a different number
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In addition, the treatment with canagliflozin induced cell apoptosis of TC cells (Wang et al., 2022)
