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Among the immune cells involved in the pathogenesis of ALI/ARDS, lung macrophages are crucial to the initiation and progression of the overwhelming pulmonary inflammation and have the potential to become a therapeutic target ( 1 , 3 )

This process amplifies inflammatory responses, contributing to the onset of CNS disorders [82]

Clinicians should maintain awareness that the absence of a recognized association does not mean patients will not experience joint symptoms during treatment, and each case warrants individual clinical assessment to determine the underlying cause and appropriate management strategy

100 A recent Phase 2b trial in obese individuals demonstrated that 32 weeks of treatment with danuglipron at doses ranging from 40 to 200 mg twice daily resulted in an average weight loss of 11.7%, whereas the placebo group exhibited 1.4% weight gain

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These findings have sparked interest in their role in addressing chronic inflammatory diseases and autoimmune conditions