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In the study, patients receiving ADI-PEG20 and docetaxel treatment displayed significant drop in plasma arginine level for the first 23 months of treatment, rise of arginine level, and ADI-PEG20 antibody at the later stage of treatment and tolerable adverse effect throughout the treatment [142]

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The transcriptional regulation of DNL is mainly orchestrated by two key transcription factors: sterol regulatory element-binding protein 1c (SREBP1c), which is activated by insulin and liver X receptor , and carbohydrate regulatory element-binding protein (ChREBP), which is activated by carbohydrates [41,42,43] (Fig

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