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For example, a daily dose of 500-1000 mcg might work for mild symptoms
Requirements of vitamin B 12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation
DOI: 10.1038/s41467-017-01114-1 Formulation strategies for therapeutic peptide stability pH, ionic strength, co-solvency
While patients typically experience efficient weight loss, they might feel lethargic and fatigued while taking the medication because of GI side effects and reduced calorie intake
It binds to plasma proteins and is transported to tissues
These two delaying factors are why patients with low B12 levels are often prescribed B12 shots instead of oral supplements
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