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Instruct patients to inform healthcare providers prior to any planned surgeries or procedures if they are taking WEGOVY [see Warnings and Precautions (5.10)]
Levels and activity of major antioxidant enzymessuperoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)are also significantly reduced, weakening the kidney's capacity to neutralize ROS (44, 45)
Effect of Glucagon on Heart
However, because Mounjaro does activate GLP-1 receptors as part of its mechanism of action, it is often grouped with GLP-1-based therapies in clinical discussions and treatment algorithms
Phase 3 tirzepatide trials show approximately 1622% body weight reduction
This is modest compared to 15% body weight reduction (30+ pounds for many patients) seen with injectable semaglutide 2.4 mg weekly in obesity trials
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