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Export of lactate, which requires the regulation of lactate transporters (MCTs), is beneficial for preventing intracellular acidification and maintaining a high rate of glycolysis
With dramatic increases in GLP-1RA prescribing, potential shortages of semaglutide, in particular, and the recent availability of generic options for liraglutide, evidence-based guidance on preferential agents within this drug class became even more important. They chose to emulate a target trial as their study design because such a framework provides the closest approximation to randomized-controlled trial (RCT)-level evidence when head-to-head trials are unlikely to be conducted due to time, cost, and feasibility constraints
MapambaDSabiILalashowiJSauliEBuzaJOlomiWet al
Hepatology (2017) 66(3):80924
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Alicic, J.J
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