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However, basal levels of phase I and most phase II drug metabolizing enzymes in HepG2 cells are very low compared to human hepatocytes (Wilkening et al., 2003
[63], deviations in the -EST pattern might be caused by ROSs impact on the protein molecules integrity, which could vary the pace at which reactive species-induced protein production occurs and change fractional activity linked to DNA damage
In a first study ( 2 O 2, GPX activity, glutathione disulfide (GSSG), cell proliferation, HA and pro-inflammatory cytokines were measured, in the presence or absence of selenium-(Methyl)-selenocysteine (SeMCys)