383,384 The secondary mtDNA depletion may exacerbate OXPHOS disturbance, increasing the production of mtROS
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This development has led to the introduction of several GLP-1 receptor agonists and DPP-4 inhibitors on the market [3], which are featured prominently in current recommendations because of their effectiveness, safety and proven cardiovascular benefits [33]
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The SUSTAIN-6 CVOT [67], performed in 3,297 patients with T2DM and ASCVD/CKD, has shown that compared to placebo, semaglutide was associated with increased retinopathy complications (3.0% versus 1.8%