The transcriptome of the rat subfornical organ is altered in response to early postnatal overnutrition
However, despite previous reports on the potential advantage posed by GLP1-based multi-agonists in the management of obesity and metabolic disease, as recently exemplified by the dramatic body weight-lowering actions of the GLP1/GIP dual agonist, tirzepatide 47 , to our knowledge, no study has addressed to date the pharmacological characterization of GLP1-based unimolecular multi-agonists for management of reproductive and metabolic alterations of PCOS, using suitable preclinical models, as pre-requisite for their application in clinics
2,3 In addition to these mechanisms, GLP-1 RAs also delay gastric emptying, thereby contributing to enhanced postprandial glucose regulation and increased satiety, ultimately supporting reduced caloric intake and weight management
Fully automated mRNA in situ hybridization (ISH) was performed using the Leica Biosystems BOND RX platform and the ready-to-use RNAscope 2.5 LSx reagent kit-red (single ISH kit, cat
Is gastric sleeve safer than long-term GLP-1 use
308 , F867F877 (2015)