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"Dulaglutide and Cardiovascular Outcomes in Type 2 Diabetes (REWIND)." Lancet, 2019
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The gut, liver, and gallbladder were not designed to be constantly stimulated by GLP-1
In parallel with MTXs most well-known targets, several NAD+-dependent enzymes were inhibited by the antifolate in vitro : 2-oxoglutarate, isocitrate, malate, pyruvate, succinate, 6-phosphogluconate and glucose-6-phosphate dehydrogenases, glutamate-cysteine ligase, glutathione reductase, and glutathione peroxidase (29)
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