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Description

Metabolic marker changes (visible in bloodwork) generally appear by week 6 to 8

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When to consider dose adjustment Severe or persistent side effects warrant evaluation

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In cancer cell lines, the mTORC1 signal can also promote de novo lipid synthesis through the sterol responsive element-binding protein (SREBP) transcription factors, which induce the expression of metabolic genes responsible for lipid biosynthesis, including fatty acid synthase (FASN) (Duvel et al., 2010)

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BMC Complement Med Ther

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Not crash-diet fast, but sustainable

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