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These substrate-use trade-offs highlight the critical need for human studies that address both performance and long-term safety outcomes (including hepatic and renal function) when using fatty-acid oxidation inhibitors

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Dose matters enormously with retatrutide because each receptor system has its own dose-response curve, and the glucagon receptor component appears to require higher doses to fully engage

Acta Derm Venereol 2011;91:5414