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Pro-apoptotic elements, BCL2 associated X, apoptosis regulator (BAX) and BCL2 antagonist/killer 1 (BAK1), drive processes such as mitochondrial outer membrane permeabilization and the creation of the mitochondrial permeability transition pore (MPTP), thus regulating the formation of pores in the outer mitochondrial membrane [112]

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Research directions that may inform future probiotic GLP-1 supplement development include: studies examining optimal Akkermansia dosing, delivery mechanisms (live versus pasteurized strains), and colonization strategies