Xie Y, Hu H, Liu M, Zhou T, Cheng X, Huang W, et al
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Intracellular alpha-ketoglutarate maintains the pluripotency of embryonic stem cells
In murine studies, deletion of the IGF-1R in skeletal muscle resulted in glucose intolerance issues ultimately leading to T2D at an early age, because, although they express insulin receptors, they cannot form hybrid or IGF-1 receptors [162]
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