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Efficacy and safety of cAMP-biased GLP-1 receptor agonist ecnoglutide versus dulaglutide in patients with type 2 diabetes and elevated glucose concentrations on metformin monotherapy (EECOH-2): A 52-week, multicentre, open-label, non-inferiority, randomised, phase 3 trial
The Phase 2 data proved that starting higher doubles GI side effects with no benefit to long-term outcomes
Meanwhile, TM1 moves inwards and folds down toward GLP-2, which contributes both polar and hydrophobic contacts to stabilize the binding
In essence, GLP-1 RAs like liraglutide may improve cognitive function and reduce dementia risk in some patients, but more research is needed to confirm these findings due to variability in study outcomes
Jr., Lee, J
Rao says
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