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Garrison, and R
Renal function: Dehydration secondary to gastrointestinal side effects can impair renal function, particularly in those with pre-existing kidney disease
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Over-the-counter analgesics such as acetaminophen (up to 3,000 mg daily for adults without liver disease) or ibuprofen (with appropriate cautions regarding gastrointestinal, cardiovascular, and kidney risks) can provide symptomatic relief for mild to moderate headaches
Yilmaz, U
Meanwhile, side-effect rates increase linearly or faster: The risk-benefit ratio gets worse as you escalate
This is very different from how our body usually works
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