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The depletion of GSH or direct inhibition of SLC7A11-GPX4 pathway results in the accumulation of PLOOH and subsequently interacts with iron to form lipid radicals [46, 62,63,64]

Phosphate-Buffered Saline (PBS): Maintains stable physiological pH (approximately 7.4) with appropriate ionic strength

10.1038/nrd.2016.153 61 WoodcockJ.LaVangeL

The findings confirmed that the benefits seen at 40 weeks were sustained, with consistent HbA1c reductions and weight loss maintained through the two-year mark