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The enzymes that constitute the de novo thymidylate pathway include cytosolic serinehydroxymethyl transferase (cSHMT), thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR)

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In December 2024, the FDA issued warning letters to four peptide vendors: Prime Peptides, Xcel Peptides, SwissChems, and Summit Research