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Crystal structures of the human CYP51A1VFV complex revealed a 2:1 inhibitor-to-enzyme binding ratio, explaining the enzymes broader substrate profile and reduced sensitivity to inhibition compared to fungal homologs [100]
Consistent data collection makes protocol adjustments more informed and outcomes more meaningful
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No one has an official label
There is much debate about whether intestinal metaplasia must be present for the diagnosis of BE or if only the presence of columnar mucosa is enough
Because they are extracts, they are heterogeneous mixtures, not single defined molecules
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