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Although fundamental 5A-1MQ and LD-mediated changes to the microbiome were identified, this work is similar to many current studies where further investigations will clarify if changes in the microbiome are causative or associative 100

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977 These beneficial effects could not be entirely attributed to glucose-lowering or natriuretic action, and are also related to maintaining the intracellular iron balance

There are also important questions about interactions and who should avoid unsupervised use

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