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It was a prospective, double-blinded, cross-over study that included 10 healthy male volunteers, aged 26 to 38 years old
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Although its precise mechanisms remain incompletely characterized, BPC157 displays exceptional pharmacodynamic potency at nanomolar doses and remarkable biostabilityresisting hydrolysis, enzymatic degradation, and gastric fluid while maintaining activity at room temperature
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Here, we could demonstrate that blocking zonulin with the specific antagonist larazotide acetate was sufficient to restore the impaired barrier function in intestinal organoid cultures exposed to complete fecal supernatants from CIA mice containing high zonulin levels
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