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Many studies are pre-clinical (animal models) or small human trials making it harder to generalize to broad populations, especially those with complex sleep disorders such as sleep apnea or chronic insomnia

Further, in randomized phase III trial, more than two hundred men with isolated HGPIN on biopsy were assessed for PCa prevention, using dutasteride 0.5 mg versus active surveillance

This might be due to the side effects of niacin, or vitamin B3

Deeper lines show improvement

2018 Aug;89(8):897-898