Degradation of any single domain changes the compound activity profile in ways that compromise research validity
Kate Hanna, spokesperson for Novo Nordisk Canada, said in an emailed statement on Tuesday that the company is considering introducing a version of semaglutide to compete with generics once they enter the Canadian market. Mina Tadrous, a pharmaceutical policy expert at the University of Toronto, called the potential move an interesting play. Because of the pricing structure (in Canada) they cant really just lower the price of their brand-name product to allow generic market entry
Early success predicts ongoing success
If an athlete was competing while intoxicated I can see the argument against that, but at the very least were in an area where the merits of whether or not something should be on the list are debatable
Then, add another three grams and follow the same timeline until you hit at a maximum of nine grams
9,474,780 (780) was filed in 2015 and is expected to expire in the U.S