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Recommended antihistamine options: Cetirizine (Zyrtec): 10mg once daily, non-drowsy, fast-acting (within 1 hour), most effective for injection site itch Loratadine (Claritin): 10mg once daily, non-drowsy, good for mild reactions Fexofenadine (Allegra): 180mg once daily, non-drowsy, least sedating option Diphenhydramine (Benadryl): 25 to 50mg every 6 hours, causes drowsiness but strongest anti-itch effect, best for severe reactions or nighttime use Strategic timing approach: Take a non-drowsy antihistamine 1 hour before your scheduled injection

This dual-coding daggerasterisk system follows WHO ICD-10 5th Edition conventions used by the NHS

Fam Pract (2006) 23(3):27985.10.1093/fampra/cml008 16 ShiptonMJThachilJ

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