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Synovial pannus is composed of neoplastic microvessels, proliferating hypertrophic synovial cells, inflammatory cells, and mechanized fibrin, exhibiting tumor-like tissue properties ( RA-FLSs exhibit tumor-like biological characteristics that facilitate pannus formation

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Melanotan I (afamelanotide) is a lab-made version of a natural skin-pigment hormone that tells your skin cells to produce more melanin, the pigment that darkens skin